Tigecyclin lernen mit den Eselsbrücken von Meditricks.de

Tigecyclin


Halt! Gültige Dienstmarke erforderlich.
Um diese Inhalte zu sehen, musst Du Dich anmelden oder einen >Zugang erwerben.

Die Anmeldung findest Du im Menü unter 'Profil'.

.e34074-21.x-anchor {margin:0.25em 0.25em 0.25em 0.25em;border-width:2px;border-style:solid;border-color:rgb(255,255,255);border-radius:0.35em 0.35em 0.35em 0.35em;font-size:1.3em;background-color:rgb(239,194,43);box-shadow:0px 0px 2px 2px rgba(0,0,0,0.08);}.e34074-22.x-anchor {margin:0.25em .25em 0.25em .25em;border-width:2px;border-style:solid;border-color:rgb(255,255,255);border-radius:0.35em;font-size:1.3em;background-color:#f2f2f2;box-shadow:0em 0em 2px 2px rgba(0,0,0,0.08);}.e34074-21.x-anchor .x-anchor-content {flex-direction:row;justify-content:center;align-items:center;padding:0.1em 0.2em 0.1em 0.2em;}.e34074-22.x-anchor .x-anchor-content {flex-direction:row;justify-content:center;align-items:center;padding:0.1em .2em .1em .2em;}.e34074-21.x-anchor[class*="active"] {border-color:#dcb500;background-color:transparent;box-shadow:0px 0px 2px 2px rgba(0,0,0,0.08);}.e34074-22.x-anchor[class*="active"] {border-color:transparent;background-color:rgb(70,128,84);box-shadow:0em 0em 2px 2px rgba(0,0,0,0.25);}.e34074-21.x-anchor .x-anchor-text {margin:5px;}.e34074-22.x-anchor .x-anchor-text {margin:5px;}.e34074-21.x-anchor .x-anchor-text-primary {font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1;color:rgb(0,0,0);}.e34074-22.x-anchor .x-anchor-text-primary {font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1;color:rgba(0,0,0,1);}.e34074-21.x-anchor[class*="active"] .x-anchor-text-primary {color:rgb(217,148,3);}.e34074-22.x-anchor[class*="active"] .x-anchor-text-primary {color:rgb(236,179,59);}.e34074-21.x-anchor .x-anchor-text-secondary {margin-top:0.35em;font-family:inherit;font-size:0.75em;font-style:normal;font-weight:400;line-height:1;color:rgba(0,0,0,1);}.e34074-22.x-anchor .x-anchor-text-secondary {margin-top:0.35em;font-family:inherit;font-size:0.75em;font-style:normal;font-weight:400;line-height:1;color:rgba(0,0,0,1);}.e34074-21.x-anchor[class*="active"] .x-anchor-text-secondary {color:rgba(0,0,0,0.5);}.e34074-22.x-anchor[class*="active"] .x-anchor-text-secondary {color:rgba(0,0,0,0.5);}.e34074-21.x-anchor .x-graphic {margin:5px;}.e34074-22.x-anchor .x-graphic {margin:5px;}.e34074-21.x-anchor .x-graphic-icon {width:auto;font-size:1.5em;color:rgb(0,0,0);background-color:transparent;}.e34074-22.x-anchor .x-graphic-icon {width:auto;font-size:1.5em;color:#dcb500;background-color:transparent;}.e34074-21.x-anchor .x-graphic-icon[class*="active"] {color:rgba(0,0,0,0.5);background-color:transparent;}.e34074-22.x-anchor .x-graphic-icon[class*="active"] {color:rgb(255,255,255);background-color:transparent;}.e34074-3.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-6.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-9.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-12.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-14.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-17.x-col {z-index:1;font-size:1em;text-align:center;background-color:transparent;}.e34074-20.x-col {z-index:1;font-size:1em;text-align:center;background-color:transparent;}.e34074-2.x-row {z-index:1;margin:0px auto 0px auto;padding:0px 0px 1em 0px;font-size:1em;background-color:transparent;}.e34074-5.x-row {z-index:1;margin:0px auto 0px auto;padding:1px;font-size:1em;background-color:transparent;}.e34074-8.x-row {z-index:1;margin:0px auto 0px auto;padding:0px 0px 1em 0px;font-size:1em;background-color:transparent;}.e34074-11.x-row {z-index:1;margin:0px auto 0px auto;padding:1px;font-size:1em;background-color:transparent;}.e34074-16.x-row {z-index:1;margin:0px auto 0px auto;padding:1px;font-size:1em;background-color:transparent;}.e34074-19.x-row {z-index:1;margin:0px auto 0px auto;padding:1px;font-size:1em;background-color:transparent;}.e34074-2 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc((1rem / 2) * -1) calc((1rem / 2) * -1);}.e34074-5 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc(((1rem / 2) + 1px) * -1) calc(((1rem / 2) + 1px) * -1);}.e34074-8 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc((1rem / 2) * -1) calc((1rem / 2) * -1);}.e34074-11 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc(((1rem / 2) + 1px) * -1) calc(((1rem / 2) + 1px) * -1);}.e34074-16 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc(((1rem / 2) + 1px) * -1) calc(((1rem / 2) + 1px) * -1);}.e34074-19 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc(((1rem / 2) + 1px) * -1) calc(((1rem / 2) + 1px) * -1);}.e34074-2 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-5 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-8 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-16 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-19 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-11 > .x-row-inner > * {margin:calc(1rem / 2) calc(1rem / 2);}.e34074-1.x-section {margin:0em;padding:45px 0px 45px 0px;background-color:transparent;z-index:1;}.e34074-4.x-text {margin:0em;padding:0em;font-family:inherit;font-size:1.25em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-7.x-text {margin:0em;padding:0em 0em 1em 0em;font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-align:center;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-10.x-text {margin:0em;padding:0em 0em 0em 0em;font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-13.x-text {margin:0em;padding:0em;font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-15.x-text {margin:0em;padding:0em;font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-18.x-text {margin:0em;padding:0em;font-family:inherit;font-size:1.25em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgb(79,79,79);background-color:transparent;}.e34074-4.x-text > :first-child {margin-top:0;}.e34074-7.x-text > :first-child {margin-top:0;}.e34074-10.x-text > :first-child {margin-top:0;}.e34074-13.x-text > :first-child {margin-top:0;}.e34074-15.x-text > :first-child {margin-top:0;}.e34074-18.x-text > :first-child {margin-top:0;}.e34074-4.x-text > :last-child {margin-bottom:0;}.e34074-7.x-text > :last-child {margin-bottom:0;}.e34074-10.x-text > :last-child {margin-bottom:0;}.e34074-13.x-text > :last-child {margin-bottom:0;}.e34074-15.x-text > :last-child {margin-bottom:0;}.e34074-18.x-text > :last-child {margin-bottom:0;}@media (max-width:479.98px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}}@media (min-width:480px) and (max-width:766.98px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 1) {flex-basis:calc(50% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 0) {flex-basis:calc(50% - 1rem);}}@media (min-width:767px) and (max-width:978.98px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 1) {flex-basis:calc(50% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 0) {flex-basis:calc(50% - 1rem);}}@media (min-width:979px) and (max-width:1199.98px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 1) {flex-basis:calc(50% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 0) {flex-basis:calc(50% - 1rem);}}@media (min-width:1200px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 1) {flex-basis:calc(50% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 0) {flex-basis:calc(50% - 1rem);}}

Hier eine Vorschau,
wie wir dieses Thema behandeln und wie unsere Eselsbrücken aussehen:

Tigecyclin lernen mit den Eselsbrücken von Meditricks.de

Tigecyclin

Inhaltliche Einleitung
Tigecyclin umgeht zwei Resistenzmechanismen gegen Tetrazykline und ist damit wirksam bei diversen Problemkeimen wie MRSA, VRE und ESBL-Bildnern. Es ist eine der Optionen bei 3- und 4-MRGN. Jedoch bestehen Hinweise auf eine erhöhte Mortalität unter Tigecyclin im Vergleich zu anderen Antibiotika. Tigecyclin ist somit eine letzte Option mangels anderer Therapie-Alternativen. Indikationen sind komplizierte Haut-, Weichteil- und intraabdominelle Infektionen mit Problemkeimen. Ein weiteres neues Tetracyclin ist Eravacyclin, ein Fluorocyclin zur Behandlung von intraabdominellen Infektionen. (Ein weiteres neues Tetrazyklin, Omadacyclin, befand sich Stand 2020 zunächst in der Zulassung in der EU. Der Antrag wurde jedoch zurückgezogen)

Basiswissen

  • Neue Tetrazykline

    Neue Cycles: Motorrad

  • NW ≈ Tetrazyklinen

     Verunfalltes Vierrad

  • Phototoxizität

    Reflektiert Sonne

  • Zahnschmelz- und Knochenstörungen

    Kaputtes Gebiss

  • Komplexbildung mit Kalzium

    Kaputte Milchflaschen

  • ...

Expertenwissen

  • (1/2) Umgeht bakterielle Resistenzmechanismen: Ribosomen-schützende Proteine

    Tigerkrallen durchdringen Protektoren (für Proteine) vom Rhino-Sohn

    Resistenzmechanismen gegen Tetrazykline basieren auf speziellen zytoplasmatischen Proteinen. Diese interagieren mit den bakteriellen Ribosomen und ermöglichen deren weitere Aktivität trotz hoher Tetrazyklin-Spiegel im Blut. Die veränderte Struktur von Tigecyclin macht es weniger empfindlich für diese Mechanismen.

  • (2/2) Umgeht bakterielle Resistenzmechanismen: Efflux-Pumpen gegen Tetrazykline

    Zerstörte Effekt-Pumpe

    Efflux-Pumpen befördern Tetrazykline aus den Erregern hinaus. Die veränderte Struktur von Tigecyclin macht es weniger empfindlich für diese Mechanismen.

  • Sehr lange Halbwertszeit und wird intravenös gegeben

    Tiger hat lange, wertvolle Haarsträhne und Infusions-Granate am Gürtel

  • ...

Beginne das Lernen mit unseren Eselsbrücken,

werde Teil der Lernrevolution.



Image

Der Raub der Mona Lisa

Die Krimi-Serie rund um die neuen Antibiotika

Neu

Die 10 neuesten Meditricks:

Gereift unter der Sonne Freiburgs.    Meditricks können süchtig machen. Wir übernehmen keine Haftung für nicht mehr löschbare Erinnerungen.