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Glykopeptide
Zu den Glykopeptidantibiotika zählen Vancomycin und Teicoplanin. Es sind Reserveantibiotika. Sie verhindern die Zellwandsynthese, wirken aber ausschließlich bei grampositiven Erregern. Vorbehalten sind sie schweren Infektionen mit Staphylokokken, inkl. MRSA, Enterokokken, Clostridien und hochresistenten Corynebakterien. Glykopeptide sind erste Wahl bei Clostridium-difficile-Infektionen und MRSA. Sie sind stark nephro- und ototoxisch.
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Grundlagen
Glycopeptide
Van mit glühenden Peptid-Schneeketten
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Grundlagen
Vancomycin und Teicoplanin
Maus mit Mütze und die Teig-Planerin
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Grundlagen
Reserveantibiotika, u.a. bei MRSA/ORSA
Konserven mit goldenen Trauben
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Eigenschaften und Wirkmechanismus
Glycopeptide wie Vancomycin sind große Moleküle
Großer Van im kantigen Molekül-Look
Ihre Größe ist für das weitere Verständnis wichtig.
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Eigenschaften und Wirkmechanismus
Komplexbildung mit D-Alanyl-D-Alanin (DADA): Bausteinblockade – vs. Murein-Synthese
Van rammt Daddy Aladin im Gabelstapler mit Steinvorrat: blockiert so den Mauerbau (von lat. murus, Mauer)
Murein ist ein Makromolekül und macht einen Großteil der bakteriellen Zellwand aus. Beta-Laktamantibiotika hemmen Enzyme, welche für die Quervernetzung der Zellwand zuständig sind. Glycopeptide blockieren dagegen die Bausteine der Zellwand.
...
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Eigenschaften und Wirkmechanismus
Teicoplanin teils bakteriostatisch
Teigplanerin hat Stativ
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Eigenschaften und Wirkmechanismus
Wg. Molekülgröße: schlecht Gewebe- und nicht Liquor-gängig
LKWs versperren Abfahrt, transportieren gewebten Stoff und Likör
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Wirkspektrum und Indikationen
Nosokomiale Infekte: Pneumonie, Sepsis oder Osteomyelitis
Krankenhauskoffer: Pneu-Money, Seppelpuppe und Markknochen
Anwendungsbeispiele für Glycopeptide bei nosokomialen Infektionen sind: Endokarditis, Pneumonie (Pneu-Money), Sepsis (Seppelpuppe), Osteomyelitis (brennender Markknochen) sowie Wund- und Fremkörperinfektionen.
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Beginne das Lernen mit unseren Eselsbrücken,
werde Teil der Lernrevolution.
Zu den Glykopeptidantibiotika zählen Vancomycin und Teicoplanin. Es sind Reserveantibiotika. Sie verhindern die Zellwandsynthese, wirken aber ausschließlich bei grampositiven Erregern. Vorbehalten sind sie schweren Infektionen mit Staphylokokken, inkl. MRSA, Enterokokken, Clostridien und hochresistenten Corynebakterien. Glykopeptide sind erste Wahl bei Clostridium-difficile-Infektionen und MRSA. Sie sind stark nephro- und ototoxisch.
