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Daptomycin
Daptomycin ist ein Reserveantibiotikum bei multiresistenten grampositiven Erregern wie MRSA und VRE. Indikationen sind schwere Infektionen mit diesen Keimen. Daptomycin-Moleküle lagern sich zusammen und bilden Poren in der bakteriellen Zellmembran (nicht Zellwand). Nun können (v.a. Kalium-)Ionen austreten, es kommt zur Depolarisation des Membranpotentials und dadurch zum bakteriellen Zelltod (es kommt nicht zur Zelllyse, wie bspw. bei den Beta-Laktam-Antibiotika). Unter Daptomycin kann es zu Muskelschäden mit Erhöhung der Creatinkinase bis hin zur Rhabdomyolyse kommen. Die Kombination mit Statinen und Fibraten ist zu vermeiden.
Daptomycin: Reserve bei multiresistenten grampositiven Problemkeimen
Dackel-Polizist-mit-Mütze: Konserven, Sondereinsatz gegen blaue Ganoven
Daptomycin bildet Poren* in der Membran (nicht Zellwand) und wirkt bakterizid
Dackel-Polizisten graben Tunnel, machen Loch in Folie und die Ganoven sterben
Daptomycin ist ein zyklisches Lipopeptid. Es oligomerisiert zu neuen Poren (Ionenkanäle; der Tunnel bzw. die beiseite geschobene Membran). Dies wirkt schlussendlich bakterizid.
Lagert sich in Anwesenheit von Calcium in Zellmbran Grampositiver ein
Hält Milchtüte
Infektionen mit multiresistenten Staphylokokken , VRSA)
Böse Gauner: Der Trauben-Ganove
Zu den erfassten multiresistenten Erregern zählen Staphylokokken mit Resistenz gegen: Methicillin/Oxacillin (MRSA/ORSA), gegen Linezolid (LRSA, gezeigt als Lineal, das vor dem Zoo liegt - dem zerstörten Spielzeug-Linien-Zoo) oder Vancomycin (VRSA; kaputter Spielzeug-Van).
MRSA/ORSA
Messer
Methicillin-/Oxacillin-resistenter Staphylococcus aureus.
...
Poren erhöhen Permeabilität* für Kationen wie Kalium und Natrium
Bananen werden aus dem Versteck entwendet
Depolarisation des Membranpotentials*
Ausgesteckter Kühlschrank (de-Polar-isiert)
Depolarisation führt zu Dysfunktion von DNA-, RNA- & Proteinsynthese – bakterizid
Chaos wegen aufgetautem Gefrierschrank: DNA-Spaghetti und Brotschneidemesser – tote Ganoven
...
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werde Teil der Lernrevolution.
Daptomycin ist ein Reserveantibiotikum bei multiresistenten grampositiven Erregern wie MRSA und VRE. Indikationen sind schwere Infektionen mit diesen Keimen. Daptomycin-Moleküle lagern sich zusammen und bilden Poren in der bakteriellen Zellmembran (nicht Zellwand). Nun können (v.a. Kalium-)Ionen austreten, es kommt zur Depolarisation des Membranpotentials und dadurch zum bakteriellen Zelltod (es kommt nicht zur Zelllyse, wie bspw. bei den Beta-Laktam-Antibiotika). Unter Daptomycin kann es zu Muskelschäden mit Erhöhung der Creatinkinase bis hin zur Rhabdomyolyse kommen. Die Kombination mit Statinen und Fibraten ist zu vermeiden.