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Daptomycin
Daptomycin ist ein Reserveantibiotikum bei multiresistenten grampositiven Erregern wie MRSA und VRE. Indikationen sind schwere Infektionen mit diesen Keimen. Daptomycin-Moleküle lagern sich zusammen und bilden Poren in der bakteriellen Zellmembran (nicht Zellwand). Nun können (v.a. Kalium-)Ionen austreten, es kommt zur Depolarisation des Membranpotentials und dadurch zum bakteriellen Zelltod (es kommt nicht zur Zelllyse, wie bspw. bei den Beta-Laktam-Antibiotika). Unter Daptomycin kann es zu Muskelschäden mit Erhöhung der Creatinkinase bis hin zur Rhabdomyolyse kommen. Die Kombination mit Statinen und Fibraten ist zu vermeiden.
Daptomycin: Reserve bei multiresistenten grampositiven Problemkeimen
Dackel-Polizist-mit-Mütze: Konserven, Sondereinsatz gegen blaue Ganoven
Daptomycin bildet Poren* in der Membran (nicht Zellwand) und wirkt bakterizid
Dackel-Polizisten graben Tunnel, machen Loch in Folie und die Ganoven sterben
Daptomycin ist ein zyklisches Lipopeptid. Es oligomerisiert zu neuen Poren (Ionenkanäle; der Tunnel bzw. die beiseite geschobene Membran). Dies wirkt schlussendlich bakterizid.
Lagert sich in Anwesenheit von Calcium in Zellmbran Grampositiver ein
Hält Milchtüte
Infektionen mit multiresistenten Staphylokokken , VRSA)
Böse Gauner: Der Trauben-Ganove
Zu den erfassten multiresistenten Erregern zählen Staphylokokken mit Resistenz gegen: Methicillin/Oxacillin (MRSA/ORSA), gegen Linezolid (LRSA, gezeigt als Lineal, das vor dem Zoo liegt - dem zerstörten Spielzeug-Linien-Zoo) oder Vancomycin (VRSA; kaputter Spielzeug-Van).
MRSA/ORSA
Messer
Methicillin-/Oxacillin-resistenter Staphylococcus aureus.
Poren erhöhen Permeabilität* für Kationen wie Kalium und Natrium
Bananen werden aus dem Versteck entwendet
Depolarisation des Membranpotentials*
Ausgesteckter Kühlschrank (de-Polar-isiert)
Depolarisation führt zu Dysfunktion von DNA-, RNA- & Proteinsynthese – bakterizid
Chaos wegen aufgetautem Gefrierschrank: DNA-Spaghetti und Brotschneidemesser – tote Ganoven
Beginne das Lernen mit unseren Eselsbrücken,
werde Teil der Lernrevolution.
Daptomycin ist ein Reserveantibiotikum bei multiresistenten grampositiven Erregern wie MRSA und VRE. Indikationen sind schwere Infektionen mit diesen Keimen. Daptomycin-Moleküle lagern sich zusammen und bilden Poren in der bakteriellen Zellmembran (nicht Zellwand). Nun können (v.a. Kalium-)Ionen austreten, es kommt zur Depolarisation des Membranpotentials und dadurch zum bakteriellen Zelltod (es kommt nicht zur Zelllyse, wie bspw. bei den Beta-Laktam-Antibiotika). Unter Daptomycin kann es zu Muskelschäden mit Erhöhung der Creatinkinase bis hin zur Rhabdomyolyse kommen. Die Kombination mit Statinen und Fibraten ist zu vermeiden.
