Daptomycin lernen mit den Eselsbrücken von Meditricks.de

Daptomycin


Halt! Gültige Dienstmarke erforderlich.
Um diese Inhalte zu sehen, musst Du Dich anmelden oder einen >Zugang erwerben.

Die Anmeldung findest Du im Menü unter 'Profil'.

.e34074-21.x-anchor {margin:0.25em 0.25em 0.25em 0.25em;border-width:2px;border-style:solid;border-color:rgb(255,255,255);border-radius:0.35em 0.35em 0.35em 0.35em;font-size:1.3em;background-color:rgb(239,194,43);box-shadow:0px 0px 2px 2px rgba(0,0,0,0.08);}.e34074-22.x-anchor {margin:0.25em .25em 0.25em .25em;border-width:2px;border-style:solid;border-color:rgb(255,255,255);border-radius:0.35em;font-size:1.3em;background-color:#f2f2f2;box-shadow:0em 0em 2px 2px rgba(0,0,0,0.08);}.e34074-21.x-anchor .x-anchor-content {flex-direction:row;justify-content:center;align-items:center;padding:0.1em 0.2em 0.1em 0.2em;}.e34074-22.x-anchor .x-anchor-content {flex-direction:row;justify-content:center;align-items:center;padding:0.1em .2em .1em .2em;}.e34074-21.x-anchor[class*="active"] {border-color:#dcb500;background-color:transparent;box-shadow:0px 0px 2px 2px rgba(0,0,0,0.08);}.e34074-22.x-anchor[class*="active"] {border-color:transparent;background-color:rgb(70,128,84);box-shadow:0em 0em 2px 2px rgba(0,0,0,0.25);}.e34074-21.x-anchor .x-anchor-text {margin:5px;}.e34074-22.x-anchor .x-anchor-text {margin:5px;}.e34074-21.x-anchor .x-anchor-text-primary {font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1;color:rgb(0,0,0);}.e34074-22.x-anchor .x-anchor-text-primary {font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1;color:rgba(0,0,0,1);}.e34074-21.x-anchor[class*="active"] .x-anchor-text-primary {color:rgb(217,148,3);}.e34074-22.x-anchor[class*="active"] .x-anchor-text-primary {color:rgb(236,179,59);}.e34074-21.x-anchor .x-anchor-text-secondary {margin-top:0.35em;font-family:inherit;font-size:0.75em;font-style:normal;font-weight:400;line-height:1;color:rgba(0,0,0,1);}.e34074-22.x-anchor .x-anchor-text-secondary {margin-top:0.35em;font-family:inherit;font-size:0.75em;font-style:normal;font-weight:400;line-height:1;color:rgba(0,0,0,1);}.e34074-21.x-anchor[class*="active"] .x-anchor-text-secondary {color:rgba(0,0,0,0.5);}.e34074-22.x-anchor[class*="active"] .x-anchor-text-secondary {color:rgba(0,0,0,0.5);}.e34074-21.x-anchor .x-graphic {margin:5px;}.e34074-22.x-anchor .x-graphic {margin:5px;}.e34074-21.x-anchor .x-graphic-icon {width:auto;font-size:1.5em;color:rgb(0,0,0);background-color:transparent;}.e34074-22.x-anchor .x-graphic-icon {width:auto;font-size:1.5em;color:#dcb500;background-color:transparent;}.e34074-21.x-anchor .x-graphic-icon[class*="active"] {color:rgba(0,0,0,0.5);background-color:transparent;}.e34074-22.x-anchor .x-graphic-icon[class*="active"] {color:rgb(255,255,255);background-color:transparent;}.e34074-3.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-6.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-9.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-12.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-14.x-col {z-index:1;font-size:1em;background-color:transparent;}.e34074-17.x-col {z-index:1;font-size:1em;text-align:center;background-color:transparent;}.e34074-20.x-col {z-index:1;font-size:1em;text-align:center;background-color:transparent;}.e34074-2.x-row {z-index:1;margin:0px auto 0px auto;padding:0px 0px 1em 0px;font-size:1em;background-color:transparent;}.e34074-5.x-row {z-index:1;margin:0px auto 0px auto;padding:1px;font-size:1em;background-color:transparent;}.e34074-8.x-row {z-index:1;margin:0px auto 0px auto;padding:0px 0px 1em 0px;font-size:1em;background-color:transparent;}.e34074-11.x-row {z-index:1;margin:0px auto 0px auto;padding:1px;font-size:1em;background-color:transparent;}.e34074-16.x-row {z-index:1;margin:0px auto 0px auto;padding:1px;font-size:1em;background-color:transparent;}.e34074-19.x-row {z-index:1;margin:0px auto 0px auto;padding:1px;font-size:1em;background-color:transparent;}.e34074-2 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc((1rem / 2) * -1) calc((1rem / 2) * -1);}.e34074-5 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc(((1rem / 2) + 1px) * -1) calc(((1rem / 2) + 1px) * -1);}.e34074-8 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc((1rem / 2) * -1) calc((1rem / 2) * -1);}.e34074-11 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc(((1rem / 2) + 1px) * -1) calc(((1rem / 2) + 1px) * -1);}.e34074-16 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc(((1rem / 2) + 1px) * -1) calc(((1rem / 2) + 1px) * -1);}.e34074-19 > .x-row-inner {flex-direction:row;justify-content:flex-start;align-items:stretch;align-content:stretch;margin:calc(((1rem / 2) + 1px) * -1) calc(((1rem / 2) + 1px) * -1);}.e34074-2 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-5 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-8 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-16 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-19 > .x-row-inner > * {flex-grow:1;margin:calc(1rem / 2) calc(1rem / 2);}.e34074-11 > .x-row-inner > * {margin:calc(1rem / 2) calc(1rem / 2);}.e34074-1.x-section {margin:0em;padding:45px 0px 45px 0px;background-color:transparent;z-index:1;}.e34074-4.x-text {margin:0em;padding:0em;font-family:inherit;font-size:1.25em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-7.x-text {margin:0em;padding:0em 0em 1em 0em;font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-align:center;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-10.x-text {margin:0em;padding:0em 0em 0em 0em;font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-13.x-text {margin:0em;padding:0em;font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-15.x-text {margin:0em;padding:0em;font-family:inherit;font-size:1em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgba(0,0,0,1);background-color:transparent;}.e34074-18.x-text {margin:0em;padding:0em;font-family:inherit;font-size:1.25em;font-style:normal;font-weight:400;line-height:1.4;letter-spacing:0em;text-transform:none;color:rgb(79,79,79);background-color:transparent;}.e34074-4.x-text > :first-child {margin-top:0;}.e34074-7.x-text > :first-child {margin-top:0;}.e34074-10.x-text > :first-child {margin-top:0;}.e34074-13.x-text > :first-child {margin-top:0;}.e34074-15.x-text > :first-child {margin-top:0;}.e34074-18.x-text > :first-child {margin-top:0;}.e34074-4.x-text > :last-child {margin-bottom:0;}.e34074-7.x-text > :last-child {margin-bottom:0;}.e34074-10.x-text > :last-child {margin-bottom:0;}.e34074-13.x-text > :last-child {margin-bottom:0;}.e34074-15.x-text > :last-child {margin-bottom:0;}.e34074-18.x-text > :last-child {margin-bottom:0;}@media (max-width:479.98px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}}@media (min-width:480px) and (max-width:766.98px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 1) {flex-basis:calc(50% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 0) {flex-basis:calc(50% - 1rem);}}@media (min-width:767px) and (max-width:978.98px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 1) {flex-basis:calc(50% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 0) {flex-basis:calc(50% - 1rem);}}@media (min-width:979px) and (max-width:1199.98px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 1) {flex-basis:calc(50% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 0) {flex-basis:calc(50% - 1rem);}}@media (min-width:1200px) {.e34074-2 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-5 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-8 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 1) {flex-basis:calc(50% - 1rem);}.e34074-16 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-19 > .x-row-inner > *:nth-child(1n - 0) {flex-basis:calc(100% - 1rem);}.e34074-11 > .x-row-inner > *:nth-child(2n - 0) {flex-basis:calc(50% - 1rem);}}

Hier eine Vorschau,
wie wir dieses Thema behandeln und wie unsere Eselsbrücken aussehen:

Daptomycin lernen mit den Eselsbrücken von Meditricks.de

Daptomycin

Inhaltliche Einleitung
Daptomycin ist ein Reserveantibiotikum bei multiresistenten grampositiven Erregern wie MRSA und VRE. Indikationen sind schwere Infektionen mit diesen Keimen. Daptomycin-Moleküle lagern sich zusammen und bilden Poren in der bakteriellen Zellmembran (nicht Zellwand). Nun können (v.a. Kalium-)Ionen austreten, es kommt zur Depolarisation des Membranpotentials und dadurch zum bakteriellen Zelltod (es kommt nicht zur Zelllyse, wie bspw. bei den Beta-Laktam-Antibiotika). Unter Daptomycin kann es zu Muskelschäden mit Erhöhung der Creatinkinase bis hin zur Rhabdomyolyse kommen. Die Kombination mit Statinen und Fibraten ist zu vermeiden.

Basiswissen

  • Daptomycin: Reserve bei multiresistenten grampositiven Problemkeimen

    Dackel-Polizist-mit-Mütze: Konserven, Sondereinsatz gegen blaue Ganoven

  • Daptomycin bildet Poren* in der Membran (nicht Zellwand) und wirkt bakterizid

    Dackel-Polizisten graben Tunnel, machen Loch in Folie und die Ganoven sterben

    Daptomycin ist ein zyklisches Lipopeptid. Es oligomerisiert zu neuen Poren (Ionenkanäle; der Tunnel bzw. die beiseite geschobene Membran). Dies wirkt schlussendlich bakterizid.

  • Lagert sich in Anwesenheit von Calcium in Zellmbran Grampositiver ein

    Hält Milchtüte

  • Infektionen mit multiresistenten Staphylokokken , VRSA)

    Böse Gauner: Der Trauben-Ganove

    Zu den erfassten multiresistenten Erregern zählen Staphylokokken mit Resistenz gegen: Methicillin/Oxacillin (MRSA/ORSA), gegen Linezolid (LRSA, gezeigt als Lineal, das vor dem Zoo liegt - dem zerstörten Spielzeug-Linien-Zoo) oder Vancomycin (VRSA; kaputter Spielzeug-Van).

  • MRSA/ORSA

    Messer

    Methicillin-/Oxacillin-resistenter Staphylococcus aureus.

  • ...

Expertenwissen

  • Poren erhöhen Permeabilität* für Kationen wie Kalium und Natrium

    Bananen werden aus dem Versteck entwendet

  • Depolarisation des Membranpotentials*

    Ausgesteckter Kühlschrank (de-Polar-isiert)

  • Depolarisation führt zu Dysfunktion von DNA-, RNA- & Proteinsynthese – bakterizid

    Chaos wegen aufgetautem Gefrierschrank: DNA-Spaghetti und Brotschneidemesser – tote Ganoven

  • ...

Beginne das Lernen mit unseren Eselsbrücken,

werde Teil der Lernrevolution.



Image

Der Raub der Mona Lisa

Die Krimi-Serie rund um die neuen Antibiotika

Neu

Die 10 neuesten Meditricks:

Gereift unter der Sonne Freiburgs.    Meditricks können süchtig machen. Wir übernehmen keine Haftung für nicht mehr löschbare Erinnerungen.