Breitspektrum-Penicilline lernen mit den Eselsbrücken von Meditricks.de

Breitspektrum-Penicilline


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Hier eine Vorschau,
wie wir dieses Thema behandeln und wie unsere Eselsbrücken aussehen:

Breitspektrum-Penicilline lernen mit den Eselsbrücken von Meditricks.de

Breitspektrum-Penicilline

Basiswissen

  • Beta-Laktamase-Hemmer enden i.d.R. auf -bactam und hemmen – sensible – Betalaktamasen

    Maulkörbe für gefräßige Hunde – Back-Tram

    Beta-Laktamase-Hemmer sind jedoch nicht gegen alle Arten von Betalaktamasen wirksam (genau wie Penicilline nicht alle Penicillin-bindenden Proteine binden können). Clavulansäure bildet bei der Endung die Ausnahme.

  • Vertreter: Clavulansäure, Sulbactam, Tazobactam

    Maulkörbe: Saures Klavier, Sultan, Tatze

    Clavulansäure wird mit Amoxicillin kombiniert, Sulbactam mit Ampicillin und Tazobactam mit Piperacillin.

  • Kovalente Bindung nach Spaltung durch Betalaktamasen – Suizidinhibitor

    Hund verbissen in Maulkorb – denkt an Galgenstrick

    Betalaktamasen spalten Beta-Laktam-Antibiotika und so auch die Beta-Laktamase-Hemmer in Fragmente (Hund zerfetzt Maulkorb). Diese Fragmente jedoch binden die Betalaktamasen kovalent – und hemmen deren weitere Tätigkeit (Hund hat sich festgebissen). Sie gelten daher als Suizidinhibitoren (Galgenstrick) – sie werden vernichtet, um die Wirkung der Betalaktamasen zu stoppen.

  • Aminopenicilline

    Minen-Stifte von Polizist Armin

    Zu den Aminopenicillinen zählen Ampicillin und Amoxicillin. Beide sind oral wirksam, da sie säurestabil sind und die Magenpassage überdauern.

  • Ampicillin, meist intravenös

    Ampel mit Spritzbesteck

  • ...

Expertenwissen

  • Clavulansäure: KI Leberinsuffizienz

    Bei saurem Klavier: kaputte Leber-im-Suff

  • Enterale Resorption von Ampicillin eingeschränkt; Amoxicillin besser resorbiert, weniger GIT-NW

    Ampel schlechter verdaulich als “I mog sie” - Lebkuchenherz

    Ampicillin wird enteral schlecht resorbiert. Dies erhöht seine gastrointestinalen Nebenwirkungen durch Schädigung der normalen Darmflora. Amoxicillin wiederum wird enteral besser resorbiert und verursacht weniger gastrointestinale Nebenwirkungen. Amoxicillin wird daher für die orale Gabe favorisiert.

  • Aminopenicilline durchdringen - im Gegensatz zu Penicillin G - die Porinkanäle gramnegativer Keime

    Minenstift-Polizist guckt - im Gegensatz zu Polizistin mit Gel-Haaren - roten Pornokanal im TV

    Penicillin G vermag nicht, die Porinkanäle (Pornokanal) der äußeren Membran gramnegativer Bakterien zu durchdringen (rote Figuren im Pornokanal). Aminopenicillinen gelingt dies (Pornokanal stört Armin nicht, tja).

  • ...

Beginne das Lernen mit unseren Eselsbrücken,

werde Teil der Lernrevolution.


Image

Der Raub der Mona Lisa

Die Krimi-Serie rund um die neuen Antibiotika

Neu

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