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Linezolid
Oxazolidinone wie Linezolid wirken gegen multiresistente grampositive Kokken (VRE, MRSA, MRSE und Streptokokken). Es sind Reserveantibiotika für Pneumonien, Weichteil- und Wundinfektionen. Linezolid hat teils schwere Nebenwirkungen wie die Myelosuppression. Möglich sind auch ein Serotonin-Syndrom bei der gleichzeitigen Einnahme von Psychopharmaka oder hypertensive Krisen in Wechselwirkung mit der Ernährung.
Oxazolidinone
Ochsen im Zoo
Reserveantibiotika gegen grampositive Kokken
Konserven mit blauen Trauben
Linezolid
Blaue Linie, die am Zoo liegt
Tedizolid
Teddy im Zoo
Hemmt 50S-UE der Ribosomen → Proteinbiosynthese-Hemmung in Initiationsphase
Am Oberkörper gefesselter Rhino-Sohn hält 50iger Schein → wollte Brot zum Füttern kaufen
Oxazolidinone verhindern die Bildung eines funktionsfähigen Initiationskomplexes zwischen Ribosom, mRNA und tRNA (Rhino Sohn kommt erst gar nicht dazu, Proteinbrot aus dem Automaten einzulösen; das Ticket erinnert an mRNA und der Zettel an tRNA).
100% Bioverfügbarkeit → orale Gabe möglich
Bio-Futter → füttert oral
Renale Elimination
Niere entsorgt Urin der Zootiere
Mit Vancomycin vergleichbare Wirksamkeit und Verträglichkeit – jedoch auch wirksam bei VRE
Van steht am Zooeingang
Linezolid hat eine mit Vancomycin vergleichbare Wirksamkeit und Verträglichkeit. Im Unterschied zu Vancomycin wirkt Linezolid jedoch auch gegen Vancomycin-resistente Enterokokken.
Beginne das Lernen mit unseren Eselsbrücken,
werde Teil der Lernrevolution.
Oxazolidinone wie Linezolid wirken gegen multiresistente grampositive Kokken (VRE, MRSA, MRSE und Streptokokken). Es sind Reserveantibiotika für Pneumonien, Weichteil- und Wundinfektionen. Linezolid hat teils schwere Nebenwirkungen wie die Myelosuppression. Möglich sind auch ein Serotonin-Syndrom bei der gleichzeitigen Einnahme von Psychopharmaka oder hypertensive Krisen in Wechselwirkung mit der Ernährung.
